Individual Differences in Gambling Proneness among Rats and Common Marmosets: An Automated Choice Task

被引:12
作者
Zoratto, Francesca [1 ,2 ]
Sinclair, Emma [1 ]
Manciocco, Arianna [1 ,3 ]
Vitale, Augusto [1 ]
Laviola, Giovanni [1 ]
Adriani, Walter [1 ]
机构
[1] Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Behav Neurosci, I-00161 Rome, Italy
[2] Bambino Gesu Pediat Hosp, IRCCS, Rome, Italy
[3] CNR, Ist Sci & Tecnol Cogniz, Rome, Italy
基金
欧盟第七框架计划;
关键词
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SPONTANEOUSLY HYPERTENSIVE-RAT; DECISION-MAKING; IMPULSIVE BEHAVIOR; CALLITHRIX-JACCHUS; PARKINSONS-DISEASE; RESPONSE CHOICE; VARYING DELAYS; ANIMAL-MODEL;
D O I
10.1155/2014/927685
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose-or hand-poking, subjects learnt to prefer a large (LLL, 5-6 pellets) over a small (SS, 1-2 pellets) reward and, subsequently, the probability of occurrence of large-reward delivery was decreased progressively to very low levels (from 100% to 17% and 14%). As probability decreased, subjects showed a great versus little shift in preference from LLL to SS reinforcer. Hence, two distinct subpopulations ("non-gambler" versus "gambler") were differentiated within each species. A proof of the model validity comes from marmosets' reaction to reward-delivery omission. Namely, depending on individual temperament ("gambler" versus "non-gambler"), they showed either persistence (i.e., inadequate pokes towards LLL) or restlessness (i.e., inadequate pokes towards SS), respectively. In conclusion, the marmoset could be a suitable model for preclinical gambling studies. Implementation of the PDT to species other than rats may be relevant for determining its external validity/generalizability and improving its face/construct validity.
引用
收藏
页数:12
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