Individual Differences in Gambling Proneness among Rats and Common Marmosets: An Automated Choice Task

被引:12
作者
Zoratto, Francesca [1 ,2 ]
Sinclair, Emma [1 ]
Manciocco, Arianna [1 ,3 ]
Vitale, Augusto [1 ]
Laviola, Giovanni [1 ]
Adriani, Walter [1 ]
机构
[1] Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Behav Neurosci, I-00161 Rome, Italy
[2] Bambino Gesu Pediat Hosp, IRCCS, Rome, Italy
[3] CNR, Ist Sci & Tecnol Cogniz, Rome, Italy
基金
欧盟第七框架计划;
关键词
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SPONTANEOUSLY HYPERTENSIVE-RAT; DECISION-MAKING; IMPULSIVE BEHAVIOR; CALLITHRIX-JACCHUS; PARKINSONS-DISEASE; RESPONSE CHOICE; VARYING DELAYS; ANIMAL-MODEL;
D O I
10.1155/2014/927685
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose-or hand-poking, subjects learnt to prefer a large (LLL, 5-6 pellets) over a small (SS, 1-2 pellets) reward and, subsequently, the probability of occurrence of large-reward delivery was decreased progressively to very low levels (from 100% to 17% and 14%). As probability decreased, subjects showed a great versus little shift in preference from LLL to SS reinforcer. Hence, two distinct subpopulations ("non-gambler" versus "gambler") were differentiated within each species. A proof of the model validity comes from marmosets' reaction to reward-delivery omission. Namely, depending on individual temperament ("gambler" versus "non-gambler"), they showed either persistence (i.e., inadequate pokes towards LLL) or restlessness (i.e., inadequate pokes towards SS), respectively. In conclusion, the marmoset could be a suitable model for preclinical gambling studies. Implementation of the PDT to species other than rats may be relevant for determining its external validity/generalizability and improving its face/construct validity.
引用
收藏
页数:12
相关论文
共 86 条
[61]   Pathological gambling is linked to reduced activation of the mesolimbic reward system [J].
Reuter, J ;
Raedler, T ;
Rose, M ;
Hand, I ;
Gläscher, J ;
Büchel, C .
NATURE NEUROSCIENCE, 2005, 8 (02) :147-148
[62]   Dimensions of impulsive behavior: Personality and behavioral measures [J].
Reynolds, B ;
Ortengren, A ;
Richards, JB ;
de Wit, H .
PERSONALITY AND INDIVIDUAL DIFFERENCES, 2006, 40 (02) :305-315
[63]   Variation of bar-press duration: Where do new responses come from? [J].
Roberts, Seth ;
Gharib, Afshin .
BEHAVIOURAL PROCESSES, 2006, 72 (03) :215-223
[64]   Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD) [J].
Sagvolden, T .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2000, 24 (01) :31-39
[65]  
Sagvolden T, 1998, BEHAV BRAIN RES, V94, P1
[66]  
Santangelo AM, 2011, J PSYCHOPHARMACOL, V25, pA73
[67]   Second-order schedules of drug self-administration in animals [J].
Schindler, CW ;
Panlilio, LV ;
Goldberg, SR .
PSYCHOPHARMACOLOGY, 2002, 163 (3-4) :327-344
[68]   Gambling and related mental disorders: A public health analysis [J].
Shaffer, HJ ;
Korn, DA .
ANNUAL REVIEW OF PUBLIC HEALTH, 2002, 23 :171-212
[69]   Individual Differences in Delay Discounting Relation to Intelligence, Working Memory, and Anterior Prefrontal Cortex [J].
Shamosh, Noah A. ;
DeYoung, Colin G. ;
Green, Adam E. ;
Reis, Deidre L. ;
Johnson, Matthew R. ;
Conway, Andrew R. A. ;
Engle, Randall W. ;
Braver, Todd S. ;
Gray, Jeremy R. .
PSYCHOLOGICAL SCIENCE, 2008, 19 (09) :904-911
[70]   A new primate model for multiple sclerosis in the common marmoset [J].
t'Hart, BA ;
van Meurs, M ;
Brok, HPM ;
Massacesi, L ;
Bauer, J ;
Boon, L ;
Bontrop, RE ;
Laman, JD .
IMMUNOLOGY TODAY, 2000, 21 (06) :290-297