Predicting benefit from anti-angiogenic agents in malignancy

被引：200

作者：

Jubb, Adrian M. ^{[1
]}

Oates, Adam J.

Holden, Scott

Koeppen, Hartmut

机构：

[1] Univ Leeds, Inst Mol Med, Acad Unit Pathol, Leeds LS2 9JT, W Yorkshire, England

[2] St James Hosp, Dept Gen Surg, Leeds LS9 7TF, W Yorkshire, England

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 08期

关键词：

D O I：

10.1038/nrc1946

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A high probability of benefit is desirable to justify the choice of anti-angiogenic therapy from an ever-expanding list of expensive new anticancer agents. However, biomarkers of response to cytotoxic agents are not optimal for predicting benefit from anti-angiogenic drugs. This discussion will focus on both preclinical and clinical research to identify biomarkers for anti-angiogenic therapies that can inform dosing, early clinical benefit, initial drug choice, emerging resistance and second-line treatments.

引用

页码：626 / 635

页数：10

共 68 条

[31] Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: Implications for trial design of antiangiogenic antibodies [J].

Jayson, GC ;

Zweit, J ;

Jackson, A ;

Mulatero, C ;

Julyan, P ;

Ranson, M ;

Broughton, L ;

Wagstaff, J ;

Hakannson, L ;

Groenewegen, G ;

Bailey, J ;

Smith, N ;

Hastings, D ;

Lawrance, J ;

Haroon, H ;

Ward, T ;

McGown, AT ;

Tang, M ;

Levitt, D ;

Marreaud, S ;

Lehmann, FF ;

Herold, M ;

Zwierzina, H .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2002, 94 (19) :1484-1493

[32] Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis [J].

Joyce, JA ;

Laakkonen, P ;

Bernasconi, M ;

Bergers, G ;

Ruoslahti, E ;

Hanahan, D .

CANCER CELL, 2003, 4 (05) :393-403

[33] Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizurnab in metastatic colorectal cancer [J].

Jubb, AM ;

Hurwitz, HI ;

Bai, W ;

Holmgren, EB ;

Tobin, P ;

Guerrero, AS ;

Kabbinavar, F ;

Holden, SN ;

Novotny, WF ;

Frantz, GD ;

Hillan, KJ ;

Koeppen, H .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (02) :217-227

[34] Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU) leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer [J].

Kabbinavar, F ;

Hurwitz, HI ;

Fehrenbacher, L ;

Meropol, NJ ;

Novotny, WF ;

Lieberman, G ;

Griffing, S ;

Bergsland, E .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) :60-65

[35] Therapeutic implications of intrinsic or induced angiogenic growth factor redundancy in tumors revealed [J].

Kerbel, RS .

CANCER CELL, 2005, 8 (04) :269-271

[36] Phase II trial of bevacizurnab plus gemcitabine in patients with advanced pancreatic cancer [J].

Kindler, HL ;

Friberg, G ;

Singh, DA ;

Locker, G ;

Nattam, S ;

Kozloff, M ;

Taber, DA ;

Karrison, T ;

Dachman, A ;

Stadler, WM ;

Vokes, EE .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (31) :8033-8040

[37]

Kumar H, 1998, CLIN CANCER RES, V4, P1279

[38]

Kuramochi H, 2006, CLIN CANCER RES, V12, P29, DOI 10.1158/1078-0432.CCR-05-1275

[39] Biomarkers for assessment of pharmacologic activity for a vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK): translation of biological activity in a mouse melanoma metastasis model to phase I studies in patients with advanced colorectal cancer with liver metastases [J].

Lee, L ;

Sharma, S ;

Morgan, B ;

Allegrini, P ;

Schnell, C ;

Brueggen, J ;

Cozens, R ;

Horsfield, M ;

Guenther, C ;

Steward, WP ;

Drevs, J ;

Lebwohl, D ;

Wood, J ;

McSheehy, PMJ .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2006, 57 (06) :761-771

[40] Phase I study of antisense oligonucleotide against vascular endothelial growth factor: Decrease in plasma vascular endothelial growth factor with potential clinical efficacy [J].

Levine, AM ;

Tulpule, A ;

Quinn, DI ;

Gorospe, G ;

Smith, DL ;

Hornor, L ;

Boswell, WD ;

Espina, BM ;

Groshen, SG ;

Masood, R ;

Gill, PS .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (11) :1712-1719

← 1 2 3 4 5 6 7 →