Future perspectives and potential implications of cardiac myocyte apoptosis

被引：33

作者：

Haunstetter, A

Izumo, S ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Cardiovasc, Boston, MA 02115 USA

[2] Univ Heidelberg, Dept Cardiol, D-6900 Heidelberg, Germany

来源：

CARDIOVASCULAR RESEARCH | 2000年 / 45卷 / 03期

关键词：

apoptosis; myocytes; growth factors; mitochondria;

D O I：

10.1016/S0008-6363(99)00264-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advances in the understanding of the molecular mechanisms of apoptosis has gained increasing interest in the cardiovascular research community. Apoptotic myocyte loss has been detected in different cardiac disease states such as ischemic heart disease and congestive heart failure. In addition, some evidence for the molecular mechanisms in cardiac myocyte apoptosis has been evolving, although at present the implications thereof for clinical cardiac disease are not known in mast of the cases. Based on these new insights, it is the intention of this article to highlight some topics in apoptosis research that might be of particular interest to define the future role and potentials of new therapeutic approaches aimed at preventing myocyte apoptosis. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：795 / 801

页数：7

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