A novel protein, Romo1, induces ROS production in the mitochondria

被引：132

作者：

Chung, Young Min

Kim, Jun Suk

Yoo, Young Do

机构：

[1] Korea Univ, Coll Med, Grad Sch Med, Seoul 136705, South Korea

[2] Korea Univ, Coll Med, Brain Korea 21 Program Biomed Sci, Seoul 136705, South Korea

[3] Korea Univ, Coll Med, Dept Internal Med, Seoul 136705, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 347卷 / 03期

关键词：

reactive oxygen species; mitochondria; Romo1;

D O I：

10.1016/j.bbrc.2006.06.140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The majority of endogenous reactive oxygen species (RCIS) are produced in the mitochondrial respiratory chain. An imbalance in ROS production alters the intracellular redox homeostasis, triggers DNA damage, and contributes to cancer development and progression. This study identified a novel protein, reactive oxygen species modulator 1 (Romo 1), which is localized in the mitochondria. Romo 1 was found to increase the level of ROS in the cells. Increased Romo1 expression was observed in various cancer cell lines. This suggests that the increased Romo1 expression during cancer progression may cause persistent oxidative stress to tumor cells, which can increase their malignancy. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：649 / 655

页数：7

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