miRNAs and aging: A genetic perspective

被引：24

作者：

Garg, Devika ^{[1
,2
]}

Cohen, Stephen M. ^{[1
,2
]}

机构：

[1] Inst Mol & Cell Biol, Singapore 138673, Singapore

[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117548, Singapore

来源：

AGEING RESEARCH REVIEWS | 2014年 / 17卷

关键词：

Genetics; Drosophila; Caenorhabditis elegans; microRNA; Aging; EXTENDS LIFE-SPAN; CAENORHABDITIS-ELEGANS; DROSOPHILA-MELANOGASTER; CALORIC RESTRICTION; C.-ELEGANS; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; DIETARY RESTRICTION; ALZHEIMERS-DISEASE; HETEROGENEOUS MICE;

D O I：

10.1016/j.arr.2014.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

A growing body of evidence shows that microRNA expression changes with age in animals ranging from nematode to human. Genetic studies of microRNA function in vivo provide the means to move beyond correlation and to explore cause-effect relationships. Genetic studies in Caenorhabditis elegans and Drosophila have identified cellular pathways involved in organismal aging. Here, we review the evidence that microRNAs act in vivo as regulators of aging pathways, with emphasis on Drosophila. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：3 / 8

页数：6

共 100 条

[1]

Diversifying microRNA sequence and function [J].

Ameres, Stefan L. ;

Zamore, Phillip D. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (08) :475-488

[2]

Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity [J].

Arum, Oge ;

Johnson, Thomas E. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2007, 62 (09) :951-959

[3]

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain [J].

Bai, Hua ;

Kang, Ping ;

Tatar, Marc .

AGING CELL, 2012, 11 (06) :978-985

[4]

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [J].

Baker, Darren J. ;

Wijshake, Tobias ;

Tchkonia, Tamar ;

LeBrasseur, Nathan K. ;

Childs, Bennett G. ;

van de Sluis, Bart ;

Kirkland, James L. ;

van Deursen, Jan M. .

NATURE, 2011, 479 (7372) :232-U112

[5]

MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging [J].

Bates, David J. ;

Li, Na ;

Liang, Ruqiang ;

Sarojini, Harshini ;

An, Jin ;

Masternak, Michal M. ;

Bartke, Andrzej ;

Wang, Eugenia .

AGING CELL, 2010, 9 (01) :1-18

[6]

Regulation of Drosophila lifespan by JNK signaling [J].

Biteau, Benoit ;

Karpac, Jason ;

Hwangbo, DaeSung ;

Jasper, Heinrich .

EXPERIMENTAL GERONTOLOGY, 2011, 46 (05) :349-354

[7]

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster [J].

Bjedov, Ivana ;

Toivonen, Janne M. ;

Kerr, Fiona ;

Slack, Cathy ;

Jacobson, Jake ;

Foley, Andrea ;

Partridge, Linda .

CELL METABOLISM, 2010, 11 (01) :35-46

[8]

A developmental timing microRNA and its target regulate life span in C. elegans [J].

Boehm, M ;

Slack, F .

SCIENCE, 2005, 310 (5756) :1954-1957

[9]

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands [J].

Broughton, SJ ;

Piper, MDW ;

Ikeya, T ;

Bass, TM ;

Jacobson, J ;

Driege, Y ;

Martinez, P ;

Hafen, E ;

Withers, DJ ;

Leevers, SJ ;

Partridge, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) :3105-3110

[10]

Insulin/IGF-like signalling, the central nervous system and aging [J].

Broughton, Susan ;

Partridge, Linda .

BIOCHEMICAL JOURNAL, 2009, 418 :1-12

← 1 2 3 4 5 6 7 8 9 10 →