Dendritic cells in intestinal homeostasis and disease

被引：294

作者：

Rescigno, Maria ^{[1
]}

Di Sabatino, Antonio ^{[2
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy

[2] Univ Pavia, S Matteo Hosp, Dept Med 1, I-27100 Pavia, Italy

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 09期

关键词：

REGULATORY T-CELLS; INFLAMMATORY-BOWEL-DISEASE; COLONIC LAMINA PROPRIA; MESENTERIC LYMPH-NODES; EPITHELIAL-CELLS; ULCERATIVE-COLITIS; INCREASED EXPRESSION; ADHESION MOLECULE-1; PROSTAGLANDIN E-2; PERIPHERAL-BLOOD;

D O I：

10.1172/JCI39134

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.

引用

页码：2441 / 2450

页数：10

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