Interleukin-12: Role of interferon-gamma in IL-12 adverse effects

被引：63

作者：

Ryffel, B

机构：

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1997年 / 83卷 / 01期

关键词：

D O I：

10.1006/clin.1996.4306

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 12 (IL-12) activates natural killer and T cells with the secondary synthesis and release of interferon-gamma (IFN-gamma) and therefore enhances a Th1- or cell-mediated immune response, The immunostimulatory property of IL-12 may be used clinically in cancer and viral diseases. Safety studies in rodents and primates demonstrated a rather small therapeutic window with hepato- and splenomegaly, myelodepression, and lung edema, Investigations in mutant mice deficient for the IFN-gamma receptor (IFN-gamma R-/-) revealed that both the biologic and toxic effects are indirect and largely due to IL-la-induced IFN-gamma. The significance of these findings for the safety in man needs to be explored. (C) 1997 Academic Press.

引用

页码：18 / 20

页数：3

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