Treponema denticola is resistant to human β-defensins

被引：38

作者：

Brissette, CA

Lukehart, SA

机构：

[1] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 07期

关键词：

D O I：

10.1128/IAI.70.7.3982-3984.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Spirochetes, including Treponema denticola, are implicated in the pathogenesis of periodontal disease. Because T. denticola lacks lipopolysaccharides that serve as targets for human beta-defensin (hbetaD) binding, we postulated that T. denticola would resist killing by hbetaD. We showed that T. denticola is resistant to hbetaD-1 and -2. Protease inhibitors did not enhance killing of T. denticola by hbetaD-2, suggesting that degradation of hbetaD-2 by treponemal proteases is not a major factor in T. denticola resistance.

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页码：3982 / 3984

页数：3

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