miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC (Publication with Expression of Concern. See vol. 14, 2019)

被引：85

作者：

Jiang, Zeyong ^{[1
]}

Yin, Jun ^{[1
]}

Fu, Wenfan ^{[1
]}

Mo, Yijun ^{[1
]}

Pan, Youguang ^{[1
]}

Dai, Lu ^{[1
]}

Huang, Haoda ^{[1
]}

Li, Siwen ^{[1
]}

Zhao, Jian ^{[1
]}

机构：

[1] Guangzhou Med Univ, Ctr Canc, Dept Chest Surg, Guangzhou, Guangdong, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 04期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TGF-BETA; MICRORNA CLUSTER; STEM-CELLS; CANCER; EXPRESSION; MIR-17-92; AXIS; EMT;

D O I：

10.1371/journal.pone.0094639

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

MicroRNAs (miRNAs) have been proven to play crucial roles in cancer, including tumor chemotherapy resistance and metastasis of non-small-cell lung cancer (NSCLC). TGF beta signal pathway abnormality is widely found in cancer and correlates with tumor proliferation, apoptosis and metastasis. Here, miR-17, 20a, 20b were detected down-regulated in A549/DDP cells (cisplatin resistance) compared with A549 cells (cisplatin sensitive). Over-expression of miR-17, 20a, 20b can not only decrease cisplatin-resistant but also reduce migration by inhibiting epithelial-to-mesenchymal transition (EMT) in A549/DDP cells. These functions of miR-17, 20a, 20b may be caused at least in part via inhibition of TGF beta signal pathway, as miR-17, 20a, 20b are shown to directly target and repress TGF-beta receptor 2 (TGF beta R2) which is an important component of TGF beta signal pathway. Consequently, our study suggests that miRNA 17 family (including miR-17, 20a, 20b) can act as TGF beta R2 suppressor for reversing cisplatin-resistant and suppressing metastasis in NSCLC.

引用

页数：9

共 31 条

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