Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming

被引:43
作者
Ashery, Uri [1 ]
Bielopolski, Noa [1 ]
Barak, Boaz [1 ]
Yizhar, Ofer [1 ]
机构
[1] Tel Aviv Univ, Dept Neurobiol, Fac Life Sci, IL-69978 Tel Aviv, Israel
基金
美国国家卫生研究院; 以色列科学基金会;
关键词
LETHAL-GIANT-LARVAE; ADRENAL CHROMAFFIN CELLS; READILY RELEASABLE POOL; SNARE CORE COMPLEXES; MYOSIN-II; NEUROTRANSMITTER RELEASE; MEMBRANE-FUSION; REGULATES EXOCYTOSIS; WD-REPEAT; C-ELEGANS;
D O I
10.1016/j.tins.2009.01.004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Priming is the process by which vesicles become available for fusion at nerve terminals and is modulated by numerous proteins and second messengers. One of the prominent members of this diverse family is tomosyn. Tomosyn has been identified as a syntaxin-binding protein; it inhibits vesicle priming, but its mode of action is not fully understood. The inhibitory activity of tomosyn depends on its N-terminal WD40-repeat domain and is regulated by the binding of its SNARE motif to syntaxin. Here, we describe new physiological information on the function of tomosyn and address possible interpretations of these results in the framework of the recently described crystal structure of the yeast tomosyn homolog Sro7. We also present possible molecular scenarios for vesicle priming and the involvement of tomosyn in these processes.
引用
收藏
页码:275 / 282
页数:8
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