The effect of ageing on grey and white matter reductions in schizophrenia

被引:37
作者
Bose, Subrata K. [1 ]
Mackinnon, Toby
Mehta, Mitul A. [3 ]
Turkheimer, Federico E. [2 ]
Howes, Oliver D. [3 ]
Selvaraj, Sudhakar [4 ]
Kempton, Matthew J. [3 ]
Grasby, Paul M. [2 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, PET Methodol, MRC Clin Sci Ctr, Fac Med, London W12 0NN, England
[2] Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Mental Hlth, London W12 0NN, England
[3] Kings Coll London, Inst Psychiat, London, England
[4] Univ Oxford, Dept Psychiat, Oxford, England
基金
英国医学研究理事会;
关键词
Schizophrenia; Magnetic resonance imaging; Voxel-based morphometry; Age; Grey matter; White matter; VOXEL-BASED MORPHOMETRY; STRUCTURAL BRAIN ABNORMALITIES; GRAY-MATTER; 1ST-EPISODE SCHIZOPHRENIA; ONSET SCHIZOPHRENIA; CLINICAL COURSE; VOLUME CHANGES; MRI DATA; METAANALYSIS; DISORDER;
D O I
10.1016/j.schres.2009.04.023
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Total brain volume and, in particular gray matter (GM) volume is reduced in patients with schizophrenia and recent studies suggest there is greater progressive loss of brain volume in the patients with schizophrenia than in normal controls. However, as the longitudinal studies do not include life-long follow-up, it is not clear if this occurs across the lifespan or only in the early phase of the illness. In this study we investigated this by studying the effects of age on brain tissue volumes in schizophrenia (n = 34, age range = 27-65 years)to test the prediction that there is a progressive loss in grey matter volume with increasing age in patients compared to healthy controls (n = 33, age range = 18-73 years). The results showed there was diminished relative GM volume loss with age in patients with schizophrenia compared to controls - in contrast to our prediction. However, there was increased relative white matter (WM) loss with age in schizophrenia. The results also replicated previous findings that patients with schizophrenia have significantly lower total (1509 versus 1596 mm(3)) and regional GM volume (755 versus 822 mm(3)) and increased cerebrospinal fluid (CSF) volume when compared to matched healthy volunteers. Overall these findings indicate that the proportion of grey matter in schizophrenia is reduced compared to controls early in the illness, and this difference diminishes with age; the corresponding effect in the proportion of WM is an increase with age compared to controls. This suggests that illness related factors may differentially affect grey and white matter, with implications for understanding the pathophysiology of schizophrenia and related psychotic disorders. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:7 / 13
页数:7
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