T cells in rheumatoid arthritis

被引:130
作者
Cope, Andrew P. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Kennedy Inst Rheumatol, London W6 8LH, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1186/ar2412
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Over the past decade and a half, advances in our understanding of the pathogenesis of immune-mediated diseases such as rheumatoid arthritis ( RA) have translated directly into benefit for patients. Much of this benefit has arisen through the introduction of targeted biological therapies. At the same time, technological advances have made it possible to define, at the cellular and molecular levels, the key pathways that influence the initiation and persistence of chronic inflammatory autoimmune reactions. As our understanding grows, it is likely that this knowledge will be translated into a second generation of biological therapies that are tailor-made for the patient. This review summarizes current perspectives on RA disease pathogenesis, with particular emphasis on what RA T cells look like, what they are likely to see, and how they contribute to persistence of the chronic inflammatory response.
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页数:10
相关论文
共 86 条
[1]   HLA-DRB1*0404 is strongly associated with anticalpastatin antibodies in rheumatoid arthritis [J].
Auger, Isabelle ;
Roudier, Chantal ;
Guis, Sandrine ;
Balandraud, Nathalie ;
Roudier, Jean .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (12) :1588-1593
[2]   Human regulatory T cells and their role in autoimmune disease [J].
Baecher-Allan, Clare ;
Hafler, David A. .
IMMUNOLOGICAL REVIEWS, 2006, 212 :203-216
[3]   T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB:: implications for rheumatoid arthritis [J].
Beech, Jonathan T. ;
Andreakos, Evangelos ;
Ciesielski, Cathleen J. ;
Green, Patricia ;
Foxwell, Brian M. J. ;
Brennan, Fionula M. .
ARTHRITIS RESEARCH & THERAPY, 2006, 8 (06)
[4]   A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis [J].
Begovich, AB ;
Carlton, VEH ;
Honigberg, LA ;
Schrodi, SJ ;
Chokkalingam, AP ;
Alexander, HC ;
Ardlie, KG ;
Huang, QQ ;
Smith, AM ;
Spoerke, JM ;
Conn, MT ;
Chang, M ;
Chang, SYP ;
Saiki, RK ;
Catanese, JJ ;
Leong, DU ;
Garcia, VE ;
McAllister, LB ;
Jeffery, DA ;
Lee, AT ;
Batliwalla, F ;
Remmers, E ;
Criswell, LA ;
Seldin, MF ;
Kastner, DL ;
Amos, CI ;
Sninsky, JJ ;
Gregersen, PK .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (02) :330-337
[5]   Antibody response to the human stress protein BiP in rheumatoid arthritis [J].
Bodman-Smith, MD ;
Corrigall, VM ;
Berglin, E ;
Cornell, HR ;
Tzioufas, AG ;
Mavragani, CP ;
Chan, C ;
Rantapää-Dahlqvist, S ;
Panayi, GS .
RHEUMATOLOGY, 2004, 43 (10) :1283-1287
[6]   Role of PTPN22 in type 1 diabetes and other autoimmune diseases [J].
Bottini, Nunzio ;
Vang, Torkel ;
Cucca, Francesco ;
Mustelin, Tomas .
SEMINARS IN IMMUNOLOGY, 2006, 18 (04) :207-213
[7]   The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction [J].
Burger, Danielle ;
Dayer, Jean-Michel .
ARTHRITIS RESEARCH & THERAPY, 2002, 4 (Suppl 3) :S169-S176
[8]   CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease [J].
Cao, DJ ;
van Vollenhoven, R ;
Klareskog, L ;
Trollmo, C ;
Malmström, V .
ARTHRITIS RESEARCH & THERAPY, 2004, 6 (04) :R335-R346
[9]  
Chabaud M, 1999, ARTHRITIS RHEUM-US, V42, P963, DOI 10.1002/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO
[10]  
2-E