Novel C-2 substituted carbapenem derivatives .3. Synthesis and biological activity of 2-(functionalised ethenyl, oxyimino methyl and alpha-[hydroxy]benzyl)-carbapenems

被引：2

作者：

Clear, NJC ^{[1
]}

Davies, JS ^{[1
]}

Eglington, AJ ^{[1
]}

Fell, SCM ^{[1
]}

Hinks, JD ^{[1
]}

Hird, NW ^{[1
]}

Hunt, E ^{[1
]}

Moss, SF ^{[1
]}

Pearson, MJ ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 03期

关键词：

D O I：

10.7164/antibiotics.50.237

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synthesis, antibacterial activity and stability to human dehydropeptidase-1 (DHP-1) of three small series of carbapenems carrying carbon-linked substituents at C-2 are described. C-2 Ethenyl carbapenems showed moderate antibacterial activity but poor stability to DHP-1. C-2 Oxyiminomethyl carbapenems demonstrated variable activity and stability. C-2 alpha-(Hydroxy)benzyl carbapenems were the most promising and showed good potency and DHP-1 stability.

引用

页码：237 / 245

页数：9

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