Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase

被引：27

作者：

Iwanowicz, EJ ^{[1
]}

Watterson, SH ^{[1
]}

Liu, CJ ^{[1
]}

Gu, HH ^{[1
]}

Mitt, T ^{[1
]}

Leftheris, K ^{[1
]}

Barrish, JC ^{[1
]}

Fleener, CA ^{[1
]}

Rouleau, K ^{[1
]}

Sherbina, NZ ^{[1
]}

Hollenbaugh, DL ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(02)00600-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel guanidine-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immunosuppressive and antiviral therapy. The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2931 / 2934

页数：4

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