Zirconium bis(amido) catalysts for asymmetric intramolecular alkene hydroamination

被引：179

作者：

Watson, Donald A. ^{[1
]}

Chiu, Melanie ^{[1
]}

Bergman, Robert G. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ORGANOMETALLICS | 2006年 / 25卷 / 20期

关键词：

D O I：

10.1021/om0606791

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In situ combination of diphosphinic amides and Zr(NMe2)(4) results in the formation of chiral zirconium bis(amido) complexes. The complexes are competent catalysts for intramolecular asymmetric alkene hydroamintion, proViding piperidines and pyrrolidines in up to 80% ee and high yield. This system utilizes an inexpensive precatalyst, readily prepared ligands and is the first asymmetric alkene hydroamination catalyst based upon a neutral zirconium bis(amido) complex.

引用

页码：4731 / 4733

页数：3

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