Concise review: Recent advances on the significance of stem cells in tissue regeneration and cancer therapies

被引：203

作者：

Mimeault, Murielle ^{[1
]}

Batra, Surinder K. ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Dept Pathol & Microbiol,Dept Biochem & Mol Biol, Omaha, NE 68198 USA

来源：

STEM CELLS | 2006年 / 24卷 / 11期

关键词：

embryonic stem cells; adult stem cells; tissue regeneration; oncogenic transformation; stem cell-based therapies;

D O I：

10.1634/stemcells.2006-0066

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In this study, we report on recent advances on the functions of embryonic, fetal, and adult stem cell progenitors for tissue regeneration and cancer therapies. We describe new procedures for derivation and maturation of these stem cells into the tissue-specific cell progenitors. The localization of the adult stem cells and their niches, as well as their implication in the tissue repair after injuries and during cancer progression, are also described. The emphasis is on the interactions among certain developmental signaling factors, such as hormones, epidermal growth factor, hedgehog, Wnt/beta-catenin, and Notch. These factors and their pathways are involved in the stringent regulation of the self-renewal and/or differentiation of adult stem cells. Novel strategies for the treatment of both diverse degenerating disorders, by cell replacement, and some metastatic cancer types, by molecular targeting multiple tumorigenic signaling elements in cancer progenitor cells, are also illustrated.

引用

页码：2319 / 2345

页数：27

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