FXR: a target for cholestatic syndromes?

被引：46

作者：

Cai, Shi-Ying

Boyer, James L.

机构：

[1] Yale Univ, Sch Med, Ctr Liver, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Med, New Haven, CT 06520 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2006年 / 10卷 / 03期

关键词：

bile acid; cholestatic liver disease; farnesoid X receptor (FXR);

D O I：

10.1517/14728222.10.3.409

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The nuclear farnesoid X receptor (FXR) plays a pivotal role in maintaining bile acid homeostasis by regulating key genes involved in bile acid synthesis, metabolism and transport, including CYP7A1, UGT2B4, BSEP, MDR3, MRP2, ASBT, I-BABP, NTCP and OST alpha-OST beta in humans. Altered expression or malfunction of these genes has been described in patients with cholestatic liver diseases. This review examines the rationale for the use of FXR ligand therapy in various cholestatic liver disorders and includes potential concerns.

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收藏

页码：409 / 421

页数：13

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