Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes

被引：40

作者：

Lale, A

Herbert, JM

Augereau, JM

Billon, M

Leconte, M

Gleye, J

机构：

[1] SANOFI RECH, F-31036 TOULOUSE, FRANCE

[2] SANOFI RECH, F-31328 CASTANET TOLOSAN, FRANCE

[3] FAC PHARMACEUT SCI, F-31062 TOULOUSE, FRANCE

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 03期

关键词：

D O I：

10.1021/np960057s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro. Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.

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页码：273 / 276

页数：4

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