Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis

被引：177

作者：

Gagneux, Sebastien

Burgos, Marcos V.

DeRiemer, Kathryn

Enciso, Antonio

Munoz, Samira

Hopewell, Phillip C.

Small, Peter M.

Pym, Alexander S.

机构：

[1] Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, CA

[2] Institute for Systems Biology, Seattle, WA

[3] Department of Internal Medicine, Division of Infectious Diseases, University of New Mexico, Albuquerque, NM

[4] Veterans Affairs Medical Center, Albuquerque, NM

[5] School of Medicine, University of California Davis, Davis, CA

[6] Unidad de Investigacion Medica de Zacatecas, Zacatecas

[7] Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA

[8] Bill and Melinda Gates Foundation, Seattle, WA

[9] Unit for Clinical and Biomedical TB Research, South African Medical Research Council, Durban

来源：

PLOS PATHOGENS | 2006年 / 2卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1371/journal.ppat.0020061

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Understanding the ecology of drug-resistant pathogens is essential for devising rational programs to preserve the effective lifespan of antimicrobial agents and to abrogate epidemics of drug-resistant organisms. Mathematical models predict that strain fitness is an important determinant of multidrug-resistant Mycobacterium tuberculosis transmission, but the effects of strain diversity have been largely overlooked. Here we compared the impact of resistance mutations on the transmission of isoniazid-resistant M. tuberculosis in San Francisco during a 9-y period. Strains with a KatG S315T or inhA promoter mutation were more likely to spread than strains with other mutations. The impact of these mutations on the transmission of isoniazid-resistant strains was comparable to the effect of other clinical determinants of transmission. Associations were apparent between specific drug resistance mutations and the main M. tuberculosis lineages. Our results show that in addition to host and environmental factors, strain genetic diversity can influence the transmission dynamics of drug-resistant bacteria.

引用

页码：603 / 610

页数：8

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