Endosome dynamics during development

被引：42

作者：

Emery, Gregory ^{[1
]}

Knoblich, Juergen A. ^{[1
]}

机构：

[1] Austrian Acad Sci, Inst Mol Biotechnol, IMBA, A-1030 Vienna, Austria

来源：

CURRENT OPINION IN CELL BIOLOGY | 2006年 / 18卷 / 04期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/j.ceb.2006.06.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endocytosis has traditionally been studied in isolated cells. More recently, however, the analysis of protein trafficking in whole organisms has revealed that it plays exciting roles during development. Endocytic trafficking of cell adhesion molecules regulates epithelial polarity and cell migration. Developmental signaling pathways are regulated by the trafficking of receptors and their ligands through the endocytic pathway. Finally, impairment of the endocytic machinery can affect proliferation control and contribute to tumor development.

引用

页码：407 / 415

页数：9