Increased sensitivity to oxidative challenges associated with topA deletion in Escherichia coli

被引：27

作者：

Tse-Dinh, YC ^{[1
]}

机构：

[1] New York Med Coll, Dept Biochem & Mol Biol, Valhalla, NY 10595 USA

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 03期

关键词：

D O I：

10.1128/JB.182.3.829-832.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.

引用

页码：829 / 832

页数：4

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