A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism

被引：68

作者：

Rogers, Steven A. ^{[1
]}

Huigens, Robert W., III ^{[1
]}

Melander, Christian ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 29期

关键词：

BACTERIAL BIOFILMS;

D O I：

10.1021/ja9024676

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identified that both inhibited and dispersed MRSA, vancomycin-resistant Enterococcus faecium, and Staphylococcus epidermidis biofilms. Mechanistic studies showed that the activity is Zn(II)-dependent, potentiatly via a direct zinc-chelating mechanism.

引用

页码：9868 / +

页数：3

共 12 条

[1] A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms [J].

Conrady, Deborah G. ;

Brescia, Cristin C. ;

Horii, Katsunori ;

Weiss, Alison A. ;

Hassett, Daniel J. ;

Herr, Andrew B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (49) :19456-19461

[2] Bacterial biofilms: A common cause of persistent infections [J].

Costerton, JW ;

Stewart, PS ;

Greenberg, EP .

SCIENCE, 1999, 284 (5418) :1318-1322

[3] Understanding biofilm resistance to antibacterial agents [J].

Davies, D .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (02) :114-122

[4] REGULATION OF SLIME PRODUCTION IN STAPHYLOCOCCUS-EPIDERMIDIS BY IRON LIMITATION [J].

DEIGHTON, M ;

BORLAND, R .

INFECTION AND IMMUNITY, 1993, 61 (10) :4473-4479

[5] Control of bacterial biofilms with marine alkaloid derivatives [J].

Huigens, Robert W., III ;

Ma, Luyan ;

Gambino, Christopher ;

Moeller, Peter D. R. ;

Basso, Anne ;

Cavanagh, John ;

Wozniak, Daniel J. ;

Melander, Christian .

MOLECULAR BIOSYSTEMS, 2008, 4 (06) :614-621

[6] Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues [J].

Huigens, Robert W., III ;

Richards, Justin J. ;

Parise, Gina ;

Ballard, T. Eric ;

Zeng, Wei ;

Deora, Rajendar ;

Melander, Christian .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (22) :6966-+

[7] Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates [J].

Huigens, Robert W., III ;

Rogers, Steven A. ;

Steinhauer, Andrew T. ;

Melander, Christian .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2009, 7 (04) :794-802

[8] Toward bifunctional antibody catalysis [J].

Kikuchi, Kazuya ;

Hannak, Renate B. ;

Guo, Mao-Jun ;

Kirby, Anthony J. ;

Hilvert, Donald .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (18) :6189-6196

[9] Chemical countermeasures for the control of bacterial biofilms: Effective compounds and promising targets [J].

Musk, Dinty J., Jr. ;

Hergenrother, Paul J. .

CURRENT MEDICINAL CHEMISTRY, 2006, 13 (18) :2163-2177

[10] PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition [J].

Peterson, Quinn P. ;

Goode, David R. ;

West, Diana C. ;

Ramsey, Kara N. ;

Lee, Joy J. Y. ;

Hergenrother, Paul J. .

JOURNAL OF MOLECULAR BIOLOGY, 2009, 388 (01) :144-158

← 1 2 →