Parallel solution phase synthesis of N-substituted 2-pyrazoline libraries

被引：28

作者：

Bauer, U ^{[1
]}

Egner, BJ ^{[1
]}

Nilsson, I ^{[1
]}

Berghult, M ^{[1
]}

机构：

[1] AstraZeneca R&D, S-43183 Molndal, Sweden

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 15期

关键词：

pyrazolines; chalcones; polymer-supported reagents/scavengers; combinatorial chemistry;

D O I：

10.1016/S0040-4039(00)00246-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The value of alpha,beta-unsaturated ketones (chalcones) as templates for the combinatorial assembly of N-substituted 2-pyrazolines has been explored. Based on a set of 80 chalcones, an array of 1500 N-carbamoyl, carbonyl and sulfonyl pyrazolines were produced demonstrating that a broad range of diversity can be fabricated around the pyrazoline motif. The efficient utilization of polymer-supported reagents and scavengers aided in providing typical purities of 75-98%. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2713 / 2717

页数：5

共 29 条

[1] Resin-supported labeling reagents [J].