Effects of alcohol and oxidative stress on liver pathology: The role of the mitochondrion

被引：88

作者：

Cahill, A

Cunningham, CC

Adachi, M

Ishii, H

Bailey, SM

Fromenty, B

Davies, A

机构：

[1] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

[2] Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC USA

[3] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan

[4] Univ Alabama, Sch Publ Hlth, Dept Environm Hlth Sci, Birmingham, AL 35294 USA

[5] Hop Beaujon, INSERM, U481, Clichy, France

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2002年 / 26卷 / 06期

关键词：

mitochondria; ethanol; oxidative stress; mitochondrial DNA; apoptosis;

D O I：

10.1111/j.1530-0277.2002.tb02621.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies.

引用

页码：907 / 915

页数：9

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