Genetic defects of the growth hormone-insulin-like growth factor axis

被引：35

作者：

López-Bermejo, A ^{[1
]}

Buckway, CK ^{[1
]}

Rosenfeld, RG ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR 97201 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1043-2760(99)00226-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our understanding of the physiology of the growth hormone-insulin-like growth factor (GH-IGF) axis has been characterized by remarkable advances in the past decade, with clarification of genetic defects in the development of somatotropes, GH secretion and action, and IGF synthesis and action. Combined efforts of research in this area and the development of animal models of growth retardation have also indicated new genetic abnormalities that might prove to cause short stature in humans. Genetic defects, both established and hypothetical, ave reviewed, and a pragmatic clinical approach to the generic investigation of short-statured patients is presented.

引用

页码：39 / 49

页数：11

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