The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

被引：581

作者：

Gerdes, Jantje M. ^{[1
]}

Davis, Erica E. ^{[1
]}

Katsanis, Nicholas ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

来源：

CELL | 2009年 / 137卷 / 01期

关键词：

BARDET-BIEDL-SYNDROME; POLYCYSTIC KIDNEY-DISEASE; PLANAR CELL POLARITY; LEFT-RIGHT ASYMMETRY; SMOOTH-MUSCLE-CELLS; INTRAFLAGELLAR TRANSPORT PROTEINS; BASAL BODY PROTEIN; JOUBERT-SYNDROME; MECKEL-SYNDROME; KINESIN-II;

D O I：

10.1016/j.cell.2009.03.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

引用

页码：32 / 45

页数：14

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