The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

被引：581

作者：

Gerdes, Jantje M. ^{[1
]}

Davis, Erica E. ^{[1
]}

Katsanis, Nicholas ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

来源：

CELL | 2009年 / 137卷 / 01期

关键词：

BARDET-BIEDL-SYNDROME; POLYCYSTIC KIDNEY-DISEASE; PLANAR CELL POLARITY; LEFT-RIGHT ASYMMETRY; SMOOTH-MUSCLE-CELLS; INTRAFLAGELLAR TRANSPORT PROTEINS; BASAL BODY PROTEIN; JOUBERT-SYNDROME; MECKEL-SYNDROME; KINESIN-II;

D O I：

10.1016/j.cell.2009.03.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

引用

页码：32 / 45

页数：14

共 118 条

[21] Vertebrate Smoothened functions at the primary cilium [J].

Corbit, KC ;

Aanstad, P ;

Singla, V ;

Norman, AR ;

Stainier, DYR ;

Reiter, JF .

NATURE, 2005, 437 (7061) :1018-1021

[22] Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms [J].

Corbit, Kevin C. ;

Shyer, Amy E. ;

Dowdle, William E. ;

Gaulden, Julie ;

Singla, Veena ;

Reiter, Jeremy F. .

NATURE CELL BIOLOGY, 2008, 10 (01) :70-U54

[23] The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome [J].

Delous, Marion ;

Baala, Lekbir ;

Salomon, Remi ;

Laclef, Christine ;

Vierkotten, Jeanette ;

Tory, Kalman ;

Golzio, Christelle ;

Lacoste, Tiphanie ;

Besse, Laurianne ;

Ozilou, Catherine ;

Moutkine, Imane ;

Hellman, Nathan E. ;

Anselme, Isabelle ;

Silbermann, Flora ;

Vesque, Christine ;

Gerhardt, Christoph ;

Rattenberry, Eleanor ;

Wolf, Matthias T. F. ;

Gubler, Marie Claire ;

Martinovic, Jelena ;

Encha-Razavi, Ferechte ;

Boddaert, Nathalie ;

Gonzales, Marie ;

Macher, Marie Alice ;

Nivet, Hubert ;

Champion, Gerard ;

Bertheleme, Jean Pierre ;

Niaudet, Patrick ;

McDonald, Fiona ;

Hildebrandt, Friedhelm ;

Johnson, Colin A. ;

Vekemans, Michel ;

Antignac, Corinne ;

Ruether, Ulrich ;

Schneider-Maunoury, Sylvie ;

Attie-Bitach, Tania ;

Saunier, Sophie .

NATURE GENETICS, 2007, 39 (07) :875-881

[24] Mutations in the CEP290 (NPHP6) gene are a frequent cause of leber congenital amaurosis [J].

den Hollander, Anneke I. ;

Koenekoop, Robert K. ;

Yzer, Suzanne ;

Lopez, Irma ;

Arends, Maarten L. ;

Voesenek, Krysta E. J. ;

Zonneveld, Marijke N. ;

Strom, Tim M. ;

Meitinger, Thomas ;

Brunner, Han G. ;

Hoyng, Carel B. ;

van den Born, L. Ingeborgh ;

Rohrschneider, Klaus ;

Cremers, Frans P. M. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 79 (03) :556-561

[25] FLAGELLAR ASSEMBLY IN 250 EASY-TO-FOLLOW STEPS [J].

DUTCHER, SK .

TRENDS IN GENETICS, 1995, 11 (10) :398-404

[26] Analysis of xbx genes in C-elegans [J].

Efimenko, E ;

Bubb, K ;

Mak, HY ;

Holzman, T ;

Leroux, MR ;

Ruvkun, G ;

Thomas, JH ;

Swoboda, P .

DEVELOPMENT, 2005, 132 (08) :1923-1934

[27] A perspective on inversin [J].

Eley, L ;

Turnpenny, L ;

Yates, LM ;

Craighead, AS ;

Morgan, D ;

Whistler, C ;

Goodship, JA ;

Strachan, T .

CELL BIOLOGY INTERNATIONAL, 2004, 28 (02) :119-124

[28] Polarity proteins control ciliogenesis via kinesin motor interactions [J].

Fan, SL ;

Hurd, TW ;

Liu, CJ ;

Straight, SW ;

Weimbs, T ;

Hurd, EA ;

Domino, SE ;

Margolis, B .

CURRENT BIOLOGY, 2004, 14 (16) :1451-1461

[29] Three types of cilia including a novel 9+4 axoneme on the notochordal plate of the rabbit embryo [J].

Feistel, Kerstin ;

Blum, Martin .

DEVELOPMENTAL DYNAMICS, 2006, 235 (12) :3348-3358

[30] Mechanisms of disease - When cilia go bad: cilia defects and ciliopathies [J].

Fliegauf, Manfred ;

Benzing, Thomas ;

Omran, Heymut .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (11) :880-893

← 1 2 3 4 5 6 7 8 9 10 →