CARB-9, a Carbenicillinase encoded in the VCR region of Vibrio cholerae Non-O1, Non-O139 belongs to a family of cassette-encoded β-lactamases

被引：33

作者：

Petroni, A

Melano, RG

Saka, HA

Garutti, A

Mange, L

Pasterán, F

Rapoport, M

Miranda, M

Faccone, D

Rossi, A

Hoffman, PS

Galas, MF

机构：

[1] INEA, ANLIS Dr Carlos G Malbran, Serv Antimicrobianos, Dept Bacteriol, RA-1281 Buenos Aires, DF, Argentina

[2] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 10期

关键词：

D O I：

10.1128/AAC.48.10.4042-4046.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The gene bla(CARB-9) was located in the Vibrio cholerae super-integron, but in a different location relative to bla(CARB-7). CARB-9 (pI 5.2) conferred beta-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla(CARB) genes indicated that the CARB enzymes constitute a family of cassette-encoded beta-lactamases.

引用

页码：4042 / 4046

页数：5

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