Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

被引：462

作者：

Chipuk, J. E. ^{[1
]}

Bouchier-Hayes, L. ^{[1
]}

Green, D. R. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2006年 / 13卷 / 08期

关键词：

apoptosis; mitochondria; BCL-2; proteins; BH3-only proteins; MOMP; membrane;

D O I：

10.1038/sj.cdd.4401963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial outer membrane permeabilization ( MOMP) is considered the 'point of no return' as this event is responsible for engaging the apoptotic cascade in numerous cell death pathways. MOMP is directly governed by a subset of the BCL-2 family of proapoptotic proteins, which induce disruptions in the outer mitochondrial membrane ( OMM) and subsequent release of death-promoting proteins like cytochrome c. The proposal here is centered on our hypothesis that MOMP is dictated by an interaction between the cytosol and the OMM, and although proteins of the OMM may be important in the process, the 'decision' to undergo apoptosis originates within the cytosol with no participation (in terms of yes, no and when) by mitochondria.

引用

页码：1396 / 1402

页数：7