Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides

被引：10

作者：

Gurvich, V

Kim, HY

Hodge, RP

Harris, CM

Harris, TM

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Ctr Mol Toxicol, Nashville, TN 37235 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 10期

关键词：

D O I：

10.1080/07328319908044885

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a useful reagent for the conversion of 6-chloropurine nucleosides to 6-fluoropurine derivatives. The 6-chloropurine nucleosides were reacted with trimethylamine to form quaternary trimethylammonium salts which were treated in situ with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yields of 59-72%.

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收藏

页码：2327 / 2333

页数：7

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