Synthesis and adduction of fully deprotected oligodeoxynucleotides containing 6-chloropurine

被引：15

作者：

Kim, HY

Nechev, L

Zhou, LA

Tamura, P

Harris, CM

Harris, TM

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Ctr Mol Toxicol, Nashville, TN 37232 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 38期

关键词：

nucleosides; nucleic acids; purines;

D O I：

10.1016/S0040-4039(98)01462-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fully deprotected oligodeoxynucleotides containing 6-chloropurine have been synthesized and used in solution phase reactions with amine nucleophiles to prepare oligonucleotides containing substituted adenine residues. This strategy was used for the preparation of a double-stranded oligonucleotide crosslinked by a 4-carbon tether between N-6 positions of deoxyadenosines in the two strands. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：6803 / 6806

页数：4

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