A mini-review: Cell response to microscale, nanoscale, and hierarchical patterning of surface structure

被引:180
作者
Jeon, HoJun [1 ]
Simon, Carl G., Jr. [2 ]
Kim, GeunHyung [1 ]
机构
[1] Sungkyunkwan Univ, Coll Biotechnol & Bioengn, Dept Biomechatron Engn, Suwon, South Korea
[2] NIST, Biosyst & Biomat Div, Gaithersburg, MD 20899 USA
基金
新加坡国家研究基金会;
关键词
cell adhesion; cell-material interactions; surface analysis; tissue engineering; OSTEOBLAST-LIKE CELLS; TOPOGRAPHICAL CONTROL; NANOIMPRINT LITHOGRAPHY; MECHANICAL-PROPERTIES; SCAFFOLD GRADIENTS; CONTACT GUIDANCE; NEURAL CELLS; TISSUE; ADHESION; DIFFERENTIATION;
D O I
10.1002/jbm.b.33158
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
Cellular behavior can be influenced by the chemical and physical surface characteristics of biomedical substrates. To understand the relationships between various topographical surface patterns and cellular activities, various types of pattern models have been developed and examined in a range of sizes (microscale, nanoscale, and hierarchical structures consisting of both) and shapes (pillar, hole, groove, grate, grid, and island). Here, we review fabrication methods for obtaining physically patterned microscale and nanoscale surfaces, and discuss the relationships between cellular responses and physically patterned surfaces, which could be applied to various biomedical scaffolds used in tissue engineering applications. (C) 2014 Wiley Periodicals, Inc.
引用
收藏
页码:1580 / 1594
页数:15
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