Peptide-mediated cell delivery: application in protein target validation

被引：161

作者：

Lindsay, MA ^{[1
]}

机构：

[1] AstraZeneca Pharmaceut, Enabling Sci & Technol Biol, Macclesfield SK10 4TG, Cheshire, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2002年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1471-4892(02)00199-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent reports have suggested that conjugation of peptides, proteins and antisense to short highly basic peptides, such as TAT, antennapedia and transportan, results in their rapid translocation into cells. Importantly, these conjugates have been shown to exert actions in a number of animal models suggesting their general utility for the determination of protein function in vitro and in vivo.

引用

页码：587 / 594

页数：8

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