The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans

被引：68

作者：

Cassata, G

Kagoshima, H

Andachi, Y

Kohara, Y

Dürrenberger, MB

Hall, DH

Bürglin, TR

机构：

[1] Univ Basel, Biozentrum, Div Cell Biol, CH-4056 Basel, Switzerland

[2] Univ Basel, Biozentrum, Interdept Electron Microscopy, CH-4056 Basel, Switzerland

[3] Natl Inst Genet, Gene Lib Lab, Mishima, Shizuoka 411, Japan

[4] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Ctr C Elegans Anat, Bronx, NY 10461 USA

来源：

NEURON | 2000年 / 25卷 / 03期

关键词：

D O I：

10.1016/S0896-6273(00)81062-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons. ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes. ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotactic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons.

引用

页码：587 / 597

页数：11

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