Biomaterials and strategies for nerve regeneration

被引:110
作者
Huang, Yi-Cheng [1 ]
Huang, Yi-You [1 ]
机构
[1] Natl Taiwan Univ, Inst Biomed Engn, Coll Engn, Coll Med, Taipei 100, Taiwan
关键词
nerve regeneration; nerve guidance channels; tissue-engineered nerve conduits;
D O I
10.1111/j.1525-1594.2006.00253.x
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Nerve regeneration is a complex biological phenomenon. Once the nervous system is impaired, its recovery is difficult and malfunctions in other parts of the body may occur because mature neurons do not undergo cell division. To increase the prospects of axonal regeneration and functional recovery, researches have focused on designing "nerve guidance channels" or "nerve conduits." When developing ideal tissue-engineered nerve conduits, several components come to mind. They include a biodegradable and porous channel wall, the ability to deliver bioactive growth factors, incorporation of support cells, an internal oriented matrix to support cell migration, intraluminal channels to mimic the structure of nerve fascicles, and electrical activities. This article reviews the factors that are critical for nerve repair, and the advanced technologies that are explored to fabricate nerve conduits. To more accurately mimic natural repair in the body, recent studies have focused on the use of various advanced approaches to create ideal nerve conduits that combine multiple stimuli in an effort to better mimic the complex signals normally found in the body.
引用
收藏
页码:514 / 522
页数:9
相关论文
共 108 条
[1]   Multilayered peptide incorporated collagen tubules for peripheral nerve repair [J].
Ahmed, MR ;
Venkateshwarlu, U ;
Jayakumar, R .
BIOMATERIALS, 2004, 25 (13) :2585-2594
[2]  
Asher R A, 2001, Prog Brain Res, V132, P611
[3]   PERSPECTIVES ON AXONAL REGENERATION IN THE MAMMALIAN CNS [J].
BAHR, M ;
BONHOEFFER, F .
TRENDS IN NEUROSCIENCES, 1994, 17 (11) :473-479
[4]   THE PERIPHERAL-NERVE ALLOGRAFT - A DOSE-RESPONSE CURVE IN THE RAT IMMUNOSUPPRESSED WITH CYCLOSPORIN-A [J].
BAIN, JR ;
MACKINNON, SE ;
HUDSON, AR ;
FALK, RE ;
FALK, JA ;
HUNTER, DA .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1988, 82 (03) :447-455
[5]  
Bain JR, 2000, MICROSURG, V20, P384, DOI 10.1002/1098-2752(2000)20:8<384::AID-MICR7>3.0.CO
[6]  
2-W
[7]   Review of current evidence for apoptosis after spinal cord injury [J].
Beattie, MS ;
Farooqui, AA ;
Bresnahan, JC .
JOURNAL OF NEUROTRAUMA, 2000, 17 (10) :915-925
[8]  
Belkas JS, 2005, RESTOR NEUROL NEUROS, V23, P19
[9]   Long-term in vivo biomechanical properties and biocompatibility of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) nerve conduits [J].
Belkas, JS ;
Munro, CA ;
Shoichet, MS ;
Johnston, M ;
Midha, R .
BIOMATERIALS, 2005, 26 (14) :1741-1749
[10]   Multi-channeled biodegradable polymer/CultiSpher composite nerve guides [J].
Bender, MD ;
Bennett, JM ;
Waddell, RL ;
Doctor, JS ;
Marra, KG .
BIOMATERIALS, 2004, 25 (7-8) :1269-1278