Differentiation and assignment of the proton NMR signals in the bis-MTPA ester of meso-alpha,alpha-dimethyl-1,4-benzenedimethanol

被引：3

作者：

Baldwin, BW ^{[1
]}

Morrow, CJ ^{[1
]}

机构：

[1] UNIV NEW MEXICO,DEPT CHEM,ALBUQUERQUE,NM 87131

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 10期

关键词：

D O I：

10.1016/0957-4166(96)00378-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

NaBH4 reduction of one ketone in 1,4-diacetylbenzene followed by Amano PS catalyzed acylation of the R enantiomer, separation of the R acetate from the S alcohol, and reduction of the remaining ketone in each with NaBD4, has provided two mixtures of monodeuterated diol diastereomers: R,R(d) plus R,S(d) and S,R(d) plus S,S(d). Conversion of the unseparated diols into their bis-(R)-MTPA (Mosher's) esters has allowed the NMR signals arising from the C-methyl groups at the R and the S ends of meso-alpha,alpha-dimethyl-1,4-benzenedimethanol bis-(R)-MTPA ester to be assigned unequivocally. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：2871 / 2878

页数：8