MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD

被引:256
作者
deToledo-Morrell, L [1 ]
Stoub, TR
Bulgakova, M
Wilson, RS
Bennett, DA
Leurgans, S
Wuu, J
Turner, DA
机构
[1] Rush Univ, Dept Neurol Sci, Chicago, IL 60612 USA
[2] Rush Univ, Dept Psychol, Chicago, IL 60612 USA
[3] Rush Univ, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA
[4] Rush Univ, Dept Diagnost Radiol & Nucl Med, Chicago, IL 60612 USA
关键词
hippocampal formation; temporal lobe; imaging; aging; memory;
D O I
10.1016/j.neurobiolaging.2003.12.007
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
With high-resolution quantitative magnetic resonance imaging (MRI) techniques, it is possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD). In the present study, 27 patients diagnosed with mild cognitive impairment (MCI) received a high-resolution MRI scan at baseline and were followed with yearly clinical evaluations. Ten of the 27 patients converted to AD during a 36-month period following the baseline clinical evaluation. Hippocampal and entorhinal cortex volumes derived from the baseline scan were compared to determine which of these two regions, known to be pathologically involved very early in the course of AD, could best differentiate MCI converters from non-converters. Although both entorhinal and hippocampal volumes were found to be independent predictors of the likelihood of conversion to AD, it was the right hemisphere entorhinal volume that best predicted conversion with a concordance rate of 93.5%. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:1197 / 1203
页数:7
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