Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood

被引:352
作者
Trouton, A [1 ]
Spinath, FM [1 ]
Plomin, R [1 ]
机构
[1] Kings Coll London, Social Genet & Dev Psychiat Res Ctr, Inst Psychiat, London SE5 8AF, England
来源
TWIN RESEARCH | 2002年 / 5卷 / 05期
基金
英国医学研究理事会;
关键词
D O I
10.1375/136905202320906255
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The Twins Early Development Study (TEDS) focuses on the early development of the three most common psychological problems in childhood: communication disorders, mild mental impairment and behavior problems. The TEDS twins were assessed longitudinally at 2, 3, 4 and 7 years of age in order to investigate genetic and environmental contributions to change and continuity in language and cognitive development; it is multivariate in order to examine the origins of comorbidity; and it uses a large sample in order to study abnormal development in the context of normal development. The twins were identified from birth records of twins born in the UK in 1994-96. More than 15,000 pairs of twins have been enrolled in TEDS and the participating families are representative of the UK. The measures at 2, 3 and 4 years are administered by parents. At 7 years, children are assessed for language and cognitive development using telephone testing, parents and children are interviewed about behavior problems, and teachers also assess behavior problems as well as academic achievement. One set of findings is that the same genes largely contribute to both language and cognitive problems and the same genes affect normal and abnormal development, a result that suggests that general impairment may be a better target for genetic research than specific language impairment independent of nonverbal cognitive problems. DNA has been obtained so far for more than 4000 pairs and is being used initially in molecular genetic studies of language problems and hyperactivity.
引用
收藏
页码:444 / 448
页数:5
相关论文
共 35 条
  • [1] BISHOP DVM, 2002, UNPUB OUTCOMES EARLY, V2
  • [2] Butler RJ, 2001, SCAND J UROL NEPHROL, V35, P177
  • [3] Neighborhood deprivation affects children's mental health: Environmental risks identified in a genetic design
    Caspi, A
    Taylor, A
    Moffitt, TE
    Plomin, R
    [J]. PSYCHOLOGICAL SCIENCE, 2000, 11 (04) : 338 - 342
  • [4] The structure of language abilities at 4 years:: A twin study
    Colledge, E
    Bishop, DVM
    Koeppen-Schomerus, G
    Price, TS
    Happé, FGE
    Eley, TC
    Dale, PS
    Plomin, R
    [J]. DEVELOPMENTAL PSYCHOLOGY, 2002, 38 (05) : 749 - 757
  • [5] Lexical and grammatical development: a behavioural genetic perspective
    Dale, PS
    Dionne, G
    Eley, TC
    Plomin, R
    [J]. JOURNAL OF CHILD LANGUAGE, 2000, 27 (03) : 619 - 642
  • [6] Genetic influence on language delay in two-year-old children
    Dale, PS
    Simonoff, E
    Bishop, DVM
    Eley, TC
    Oliver, B
    Price, TS
    Purcell, S
    Stevenson, J
    Plomin, R
    [J]. NATURE NEUROSCIENCE, 1998, 1 (04) : 324 - 328
  • [7] DALE PS, 2002, UNPUB OUTCOMES EARLY, V1
  • [8] Eley TC, 1999, DEV PSYCHOL, V35, P1122
  • [9] Longitudinal analysis of the genetic and environmental influences on components of cognitive delay in preschoolers
    Eley, TC
    Dale, P
    Bishop, D
    Price, TS
    Plomin, R
    [J]. JOURNAL OF EDUCATIONAL PSYCHOLOGY, 2001, 93 (04) : 698 - 707
  • [10] Sex differences in early verbal and non-verbal cognitive development
    Galsworthy, Michael J.
    Dionne, Ginette
    Dale, Philip S.
    Plomin, Robert
    [J]. DEVELOPMENTAL SCIENCE, 2000, 3 (02) : 206 - 215