Structural characterization of human Ad4BP (SF-1) gene

被引:59
作者
Oba, K
Yanase, T
Nomura, M
Morohashi, K
Takayanagi, R
Nawata, H
机构
[1] KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 3,HIGASHI KU,FUKUOKA 812,JAPAN
[2] KYUSHU UNIV,FAC MED,GRAD SCH MED SCI,DEPT MOL BIOL,HIGASHI KU,FUKUOKA 812,JAPAN
关键词
D O I
10.1006/bbrc.1996.1343
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ad4BP (or steroidogenic factor 1, SF-1) has been implicated to be an essential transcriptional factor for steroidogenesis as well as for the development of the reproductive axis. We elucidated the structure of the human Ad4BP gene. The gene is about 30 kb long and is split into 7 exons including a non-coding exon 1. The deduced amino acid sequence of the human Ad4BP consists of 461 amino acid residues and was highly homologous to those of other mammalian species. (C) 1996 Academic Press, Inc.
引用
收藏
页码:261 / 267
页数:7
相关论文
共 24 条
  • [1] POLYMORPHIC DNA REGION ADJACENT TO THE 5'-END OF THE HUMAN INSULIN GENE
    BELL, GI
    KARAM, JH
    RUTTER, WJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09): : 5759 - 5763
  • [2] HORMONAL AND DEVELOPMENTAL REGULATION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEIN
    CLARK, BJ
    SOO, SC
    CARON, KM
    IKEDA, Y
    PARKER, KL
    STOCCO, DM
    [J]. MOLECULAR ENDOCRINOLOGY, 1995, 9 (10) : 1346 - 1355
  • [3] THE STEROID AND THYROID-HORMONE RECEPTOR SUPERFAMILY
    EVANS, RM
    [J]. SCIENCE, 1988, 240 (4854) : 889 - 895
  • [4] HONDA S, 1993, J BIOL CHEM, V268, P7494
  • [5] CHARACTERIZATION OF THE MOUSE FTZ-F1 GENE, WHICH ENCODES A KEY REGULATOR OF STEROID HYDROXYLASE GENE-EXPRESSION
    IKEDA, Y
    LALA, DS
    LUO, XR
    KIM, E
    MOISAN, MP
    PARKER, KL
    [J]. MOLECULAR ENDOCRINOLOGY, 1993, 7 (07) : 852 - 860
  • [6] THE NUCLEAR RECEPTOR STEROIDOGENIC FACTOR-1 ACTS AT MULTIPLE LEVELS OF THE REPRODUCTIVE AXIS
    INGRAHAM, HA
    LALA, DS
    IKEDA, Y
    LUO, XR
    SHEN, WH
    NACHTIGAL, MW
    ABBUD, R
    NILSON, JH
    PARKER, KL
    [J]. GENES & DEVELOPMENT, 1994, 8 (19) : 2302 - 2312
  • [7] STEROIDOGENIC FACTOR-I, A KEY REGULATOR OF STEROIDOGENIC ENZYME EXPRESSION, IS THE MOUSE HOMOLOG OF FUSHI-TARAZU-FACTOR-1
    LALA, DS
    RICE, DA
    PARKER, KL
    [J]. MOLECULAR ENDOCRINOLOGY, 1992, 6 (08) : 1249 - 1258
  • [8] FTZ-F1, A STEROID-HORMONE RECEPTOR LIKE PROTEIN IMPLICATED IN THE ACTIVATION OF FUSHI-TARAZU
    LAVORGNA, G
    UEDA, H
    CLOS, J
    WU, C
    [J]. SCIENCE, 1991, 252 (5007) : 848 - 851
  • [9] A CELL-SPECIFIC NUCLEAR RECEPTOR IS ESSENTIAL FOR ADRENAL AND GONADAL DEVELOPMENT AND SEXUAL-DIFFERENTIATION
    LUO, XR
    IKEDA, YY
    PARKER, KL
    [J]. CELL, 1994, 77 (04) : 481 - 490
  • [10] MOROHASHI K, 1992, J BIOL CHEM, V267, P17913