Calcineurin plays different roles in group II metabotropic glutamate receptor- and NMDA receptor-dependent long-term depression

被引：31

作者：

Li, ST

Kato, K

Tomizawa, K

Matsushita, M

Moriwaki, A

Matsui, H

Mikoshiba, K

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Physiol, Okayama 7008558, Japan

[2] Japan Sci & Technol Corp, Mikoshiba Calciosignal Net Project, Tokyo 1130021, Japan

[3] Kochi Med Sch, Dept Neuropsychiat, Kochi 7838505, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Basic Med Sci, Div Mol Neurobiol, Tokyo 1088639, Japan

[5] Japan Sci & Technol Corp, Calcium Oscillat Project, Tokyo 1088639, Japan

[6] RIKEN, Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 3510198, Japan

来源：

JOURNAL OF NEUROSCIENCE | 2002年 / 22卷 / 12期

关键词：

synaptic plasticity; long-term potentiation; LTD; mGluR; NMDA receptor; hippocampus;

D O I：

10.1523/JNEUROSCI.22-12-05034.2002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated metabotropic glutamate receptor (mGluR) dependent long-term depression (LTD) in hippocampal CA1 pyramidal neurons of 6- to 8-d-old [postnatal days 6- 8 (P6-P8)] and 21- to 25-d-old (P21-P25) rats. In P6-P8 rats, induction of LTD depended on the activity of group II mGluRs. In P21-P25 rats, however, this LTD disappeared, and instead, NMDA receptor (NMDAR)-dependent LTD appeared. A bath containing a specific calcineurin (CaN) inhibitor restored the group II mGluR-dependent LTD in the neurons of the P21-P25 rats. Although postsynaptic injection of CaN inhibitors suppressed NMDAR-dependent LTD, it did not affect induction of group II mGluR-dependent LTD. These results demonstrate that CaN plays different roles in the induction of two forms of LTD: presynaptic CaN inhibits group II mGluR-dependent LTD, whereas postsynaptic CaN facilitates NMDAR-dependent LTD. These findings are the first demonstration in vitro of group II mGluR-dependent LTD that is negatively regulated by CaN via an age-dependent mechanism.

引用

页码：5034 / 5041

页数：8

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