Receptor clustering: Nothing succeeds like success

被引:3
作者
Griffith, LC
机构
[1] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA
[2] Brandeis Univ, Volen Ctr Complex Syst, Waltham, MA 02454 USA
关键词
D O I
10.1016/j.cub.2004.05.031
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
By experimentally limiting the amount of receptor molecules available in a postsynaptic neuron in Drosophila, it has been shown that receptors can preferentially cluster opposite active zones with a high release probability. This asymmetry in receptor distribution can alter the apparent probability and calcium-dependence of neurotransmiitter release.
引用
收藏
页码:R413 / R415
页数:3
相关论文
共 11 条
[1]   AMPA receptor trafficking at excitatory synapses [J].
Bredt, DS ;
Nicoll, RA .
NEURON, 2003, 40 (02) :361-379
[2]   Developmental regulation of glutamate receptor field size by nonvesicular glutamate release [J].
Featherstone, DE ;
Rushton, E ;
Broadie, K .
NATURE NEUROSCIENCE, 2002, 5 (02) :141-146
[3]  
GORCZYCA M, 1993, J NEUROSCI, V13, P3692
[4]   VARIATION IN THE NUMBER, LOCATION AND SIZE OF SYNAPTIC VESICLES PROVIDES AN ANATOMICAL BASIS FOR THE NONUNIFORM PROBABILITY OF RELEASE AT HIPPOCAMPAL CA1 SYNAPSES [J].
HARRIS, KM ;
SULTAN, P .
NEUROPHARMACOLOGY, 1995, 34 (11) :1387-1395
[5]   Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction [J].
Marrus, SB ;
Portman, SL ;
Allen, MJ ;
Moffat, KG ;
DiAntonio, A .
JOURNAL OF NEUROSCIENCE, 2004, 24 (06) :1406-1415
[6]   Inactivity produces increases in neurotransmitter release and synapse size [J].
Murthy, VN ;
Schikorski, T ;
Stevens, CF ;
Zhu, YL .
NEURON, 2001, 32 (04) :673-682
[7]   Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release [J].
Petersen, SA ;
Fetter, RD ;
Noordermeer, JN ;
Goodman, CS ;
DiAntonio, A .
NEURON, 1997, 19 (06) :1237-1248
[8]   Neural activity affects distribution of glutamate receptors during neuromuscular junction formation in Drosophila embryos [J].
Saitoe, M ;
Tanaka, S ;
Takata, K ;
Kidokoro, Y .
DEVELOPMENTAL BIOLOGY, 1997, 184 (01) :48-60
[9]   Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release [J].
Saitoe, M ;
Schwarz, TL ;
Umbach, JA ;
Gundersen, CB ;
Kidokoro, Y .
SCIENCE, 2001, 293 (5529) :514-517
[10]   Meaningless minis? Mechanisms of neurotransmitter-receptor clustering [J].
Verstreken, P ;
Bellen, HJ .
TRENDS IN NEUROSCIENCES, 2002, 25 (08) :383-385