Novel aspects in the regulation of the leukocyte adhesion cascade

被引：78

作者：

Chavakis, Emmanouil ^{[2
]}

Choi, Eun Young ^{[1
]}

Chavakis, Triantafyllos ^{[1
]}

机构：

[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

[2] Goethe Univ Frankfurt, Dept Internal Med 3, Inst Cardiovasc Regenerat, Frankfurt, Germany

来源：

THROMBOSIS AND HAEMOSTASIS | 2009年 / 102卷 / 02期

关键词：

Adhesion receptors; cell-cell interactions; endothelial cells; inflammation; integrins; EXTRACELLULAR ADHERENCE PROTEIN; ENDOTHELIAL-CELL-INTERACTIONS; MIGRATION IN-VITRO; TRANSENDOTHELIAL MIGRATION; INTEGRIN ACTIVATION; CYTOPLASMIC DOMAIN; LFA-1; ACTIVATION; INSIDE-OUT; OUTSIDE-IN; NEUTROPHIL RECRUITMENT;

D O I：

10.1160/TH08-12-0844

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leukocyte recruitment plays a major role in the immune response to infectious pathogens and during inflammatory and autoimmune disorders. The process of leukocyte extravasation from the blood into the inflamed tissue requires a complex cascade of adhesive events between the leukocytes and the endothelium including leukocyte rolling, adhesion and trans-endothelial migration. Leukocyte-endothelial interactions are mediated by tightly regulated binding interactions between adhesion receptors on both cells. In this regard, leukocyte adhesion onto the endothelium is governed by leukocyte integrins and their endothelial counter-receptors of the immunoglobulin superfamily. The present review will focus on novel aspects with respect to the modulation of the leukocyte adhesion cascade.

引用

页码：191 / 197

页数：7

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