Enantioselective hydride transfer hydrogenation of ketones catalyzed by [(η6-p-cymene)Ru(amino acidato)Cl] and [(η6-p-cymene)Ru(amino acidato)]3(BF4)3 complexes

被引：92

作者：

Kathó, A

Carmona, D

Viguri, F

Remacha, CD

Kovács, J

Joó, F

Oro, LA

机构：

[1] Univ Debrecen, Inst Phys Chem, H-4010 Debrecen 10, Hungary

[2] Univ Zaragoza, CSIC, Inst Ciencia Mat Aragon, Escuela Univ Ingn Tecn Ind,Dept Quim Inorgan, E-50009 Zaragoza, Spain

[3] Hungarian Acad Sci, Res Grp Homogenous Catalysis, H-4010 Debrecen, Hungary

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2000年 / 593卷

基金：

匈牙利科学研究基金会;

关键词：

amino acids; asymmetric catalysis; hydrogenation; ketones; ruthenium;

D O I：

10.1016/S0022-328X(99)00433-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The new complexes (R-Ru, S-C, SRuSC)-[(eta(6)-pCym)Ru(L-Aze)Cl] (6a, b), (RRuSC, SRuSC)-[(eta(6)-pCym)Ru(L-Pip)Cl] (7a, b), (RRuRRuRRuSCSCSCSNSNSN, SRuSRuSRuSCSCSCSNSNSN)-[{(eta(6)-pCym)Ru(L-Aze)}(3)](BF4)(3) (8a, b) and (RRuRRuRRuSCSCSCSNSNSN, SRuSRuSRuSCSCSCSNSNSN)-[{(eta(6)-pCym)Ru(L-Pip)}(3)](BF4)(3) (9a, b) (L-Aze = L-2-azetidinecarboxylate, L-Pip = L-2-piperidinecarboxylate) were prepared, characterized and used, together with the known [{(eta(6)-pCym)Ru(L-Pro)}(3)](BF4)(3), 5 and [{(eta(6)-pCym)Ru(L-Ala)}(3)](BF4)(3), 10 (L-Pro = L-prolinate, L-Ala = L-alaninate), in hydride transfer reduction of acetophenone, a series of substituted acetophenones and several other ketones with moderate to high conversions and enantioselectivities up to 86% e.e. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：299 / 306

页数：8

共 36 条

[1] Asymmetric catalysis.: Part 127:: Enantioselective desymmetrization of 2-n-butyl-4,7-dihydro-1,3-dioxepin with (η6-arene)ruthenium(II) half-sandwich complexes [J].