The love-hate relationship between bacterial polysaccharides and the host immune system

被引：264

作者：

Mazmanian, Sarkis K.

Kasper, Dennis L.

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab,Dept Med, Boston, MA 02115 USA

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 11期

关键词：

D O I：

10.1038/nri1956

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article explores the fascinating relationship between the mammalian immune system and the bacteria that are present in the mammalian gut. Every human is an ecosystem that hosts 10(13)-10(14) bacteria. We review the evidence that immunomodulatory molecules produced by commensal bacteria in the gut have a beneficial influence on the development of certain immune responses, through eliciting the clonal expansion of CD4(+) T-cell populations. This process seems to contribute to the overall health of the host by offering protection against various diseases and might provide supporting evidence at a molecular level for the 'hygiene hypothesis' of allergic immune disorders.

引用

页码：849 / 858

页数：10