Fabrication of a micro needle for a trace blood test

被引:77
作者
Oka, K
Aoyagi, S
Arai, Y
Isono, Y
Hashiguchi, G
Fujita, H
机构
[1] Kansai Univ, Fac Engn, Suita, Osaka 5648680, Japan
[2] Kagawa Univ, Fac Engn, Takamatsu, Kagawa 7610396, Japan
[3] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan
关键词
micro needle; jagged and hollow shape; mosquito; blood test; strength characteristics;
D O I
10.1016/S0924-4247(01)00872-X
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
A human being has pain and fear when pricked by a needle in a blood test. On the other hand, he has almost no pain and no fear when pricked by a needle of a mosquito. Considering this fact, a new fabrication process of a micro hollow needle, which is made of SiO2 and reinforced by deposited Poly-Si, is proposed. This needle features its jagged shape like that of a mosquito, and it also features its long shape of about I mm in the direction parallel to the silicon surface. The essential points of the process are as follows: (1) wet-etching a jagged groove on Si; (2) bonding another Si substrate and sealing the grooved (3) oxidizing the wall of hollow space: (14) dry etching all parts besides the wall by ICP and RIE. Strength characteristics of the fabricated needle is investigated by experiment and finite element method simulation. It is also experimentally confirmed that this needle can actually penetrate the surface of hard silicon rubber, which is selected as an artificial skin, without breakage. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:478 / 485
页数:8
相关论文
共 14 条
[1]  
Abe H, 1996, DATA BOOK MECH PROPE
[2]  
[Anonymous], INTERFACE MOSQUITOES
[3]   A multichannel neural probe for selective chemical delivery at the cellular level [J].
Chen, JK ;
Wise, KD ;
Hetke, JF ;
Bledsoe, SC .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1997, 44 (08) :760-769
[4]   Micromachined electrodes for biopotential measurements [J].
Griss, P ;
Enoksson, P ;
Tolvanen-Laakso, HK ;
Meriläinen, P ;
Ollmar, S ;
Stemme, G .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2001, 10 (01) :10-16
[5]   Micromachined needles for the transdermal delivery of drugs [J].
Henry, S ;
McAllister, DV ;
Allen, MG ;
Prausnitz, MR .
MICRO ELECTRO MECHANICAL SYSTEMS - IEEE ELEVENTH ANNUAL INTERNATIONAL WORKSHOP PROCEEDINGS, 1998, :494-498
[6]   Silicon-processed microneedles [J].
Lin, LW ;
Pisano, AP .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 1999, 8 (01) :78-84
[7]  
MCALLISTER SR, 1998, KAN JL PUB POLY, V7, P1
[8]  
*MEMS CLEAR HOUS, MEMS MAT DAT
[9]  
*MSC SOFTW CORP, 2000, MSC NASTR WIND QUICK
[10]   STRENGTH CHARACTERIZATION OF SILICON MICROPROBES IN NEUROPHYSIOLOGICAL TISSUES [J].
NAJAFI, K ;
HETKE, JF .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1990, 37 (05) :474-481