Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited

被引：325

作者：

Loges, Sonja ^{[1
,2
]}

Mazzone, Massimiliano ^{[1
,2
]}

Hohensinner, Philipp ^{[1
,2
]}

Carmeliet, Peter ^{[1
,2
]}

机构：

[1] VIB, Vesalius Res Ctr, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Vesalius Res Ctr, B-3000 Louvain, Belgium

来源：

CANCER CELL | 2009年 / 15卷 / 03期

关键词：

ENDOTHELIAL GROWTH-FACTOR; PACLITAXEL PLUS BEVACIZUMAB; TUMOR VASCULATURE; CANCER; RECEPTOR; ANGIOGENESIS; CHEMOTHERAPY; PROGRESSION; IRINOTECAN; EFFICACY;

D O I：

10.1016/j.ccr.2009.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical practice reveals that therapy with angiogenesis inhibitors often does not prolong survival of cancer patients for more than months, because tumors elicit evasive resistance. In this issue of Cancer Cell, two papers report that VEGF inhibitors reduce primary tumor growth but promote tumor invasiveness and metastasis. These perplexing findings help to explain resistance to these drugs but raise pertinent questions of how to best treat cancer patients with antiangiogenic medicine in the future. We discuss here how VEGF inhibitors can induce such divergent effects on primary tumor growth and metastasis.

引用

页码：167 / 170

页数：4

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