The role of soy phytoestrogens in prostate cancer

被引：44

作者：

Castle, EP ^{[1
]}

Thrasher, JB ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Surg, Div Urol, Kansas City, KS 66160 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2002年 / 29卷 / 01期

关键词：

D O I：

10.1016/S0094-0143(02)00019-8

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological data of phytoestrogens and prostate cancer strongly supports the cancer protective effects of isoflavones found in soy products. Inhibition of cell proliferation via hormone-dependent and hormone-independent mechanisms by soy phytochemicals has been studied extensively in cell culture and animal studies. Herein, we review the current literature on the epidemiology and effects of two soy phytoestrogens, genistein and daidzein, and would stress the need for controlled human trials to assess the true preventive and therapeutic effects of these compounds.

引用

页码：71 / +

页数：13

共 62 条

[11] COWARD L, 1993, J AGR FOOD CHEM, V41, P1961, DOI 10.1021/jf00035a027
[12] Dalu A, 1998, PROSTATE, V37, P36
[13] IMMUNODETECTION AND QUANTITATION OF THE 2 FORMS OF TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA-1 AND TGF-BETA-2) SECRETED BY CELLS IN CULTURE
DANIELPOUR, D
DART, LL
FLANDERS, KC
ROBERTS, AB
SPORN, MB
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (01) : 79 - 86
[14] FUNCTIONAL-ANALYSIS OF THE TRANSFORMING GROWTH-FACTOR-BETA RESPONSIVE ELEMENTS IN THE WAF1/CIP1/P21 PROMOTER
DATTO, MB
YU, Y
WANG, XF
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (48) : 28623 - 28628
[15] Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells
Davis, JN
Singh, B
Bhuiyan, M
Sarkar, FH
[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1998, 32 (03): : 123 - 131
[16] Diet and its preventive role in prostatic disease
Denis, L
Morton, MS
Griffiths, K
[J]. EUROPEAN UROLOGY, 1999, 35 (5-6) : 377 - 387
[17] FOTSIS T, 1995, J NUTR, V125, pS790, DOI 10.1093/jn/125.suppl_3.790S
[18] GENISTEIN, A DIETARY-DERIVED INHIBITOR OF INVITRO ANGIOGENESIS
FOTSIS, T
PEPPER, M
ADLERCREUTZ, H
FLEISCHMANN, G
HASE, T
MONTESANO, R
SCHWEIGERER, L
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) : 2690 - 2694
[19] Geller J, 1998, PROSTATE, V34, P75
[20] Certain aspects of molecular endocrinology that relate to the influence of dietary factors on the pathogenesis of prostate cancer
Griffiths, K
Morton, MS
Denis, L
[J]. EUROPEAN UROLOGY, 1999, 35 (5-6) : 443 - 455

← 1 2 3 4 5 6 7 →