Using protein folding rates to test protein folding theories

被引：56

作者：

Gillespie, B ^{[1
]}

Plaxco, KW

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Interdept Program Biomol Sci & Engn, Santa Barbara, CA 93106 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2004年 / 73卷

关键词：

simulation; nucleation; topomer search;

D O I：

10.1146/annurev.biochem.73.011303.073904

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fastest simple, kinetically two-state protein folds a million times more rapidly than the slowest. Here we review many recent theories of protein folding kinetics in terms of their ability to qualitatively rationalize, if not quantitatively predict, this fundamental experimental observation.

引用

页码：837 / 859

页数：23

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