Fatty acid synthase and cancer: New application of an old pathway

被引：530

作者：

Kuhajda, FP

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21218 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 12期

关键词：

D O I：

10.1158/0008-5472.CAN-05-4673

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer.

引用

页码：5977 / 5980

页数：4